BIOIMMUNAS
PLUS
Food supplement with extracts of morinda citrifolia, sambucus nigra, ribes nigrum, echinacea angustifolia and lactic ferments with antioxidant activity and immunostimulant properties, a support in the management and prevention of seasonal upper respiratory tract infections and useful in conditions of reduced immune defences, in paediatrics and during chronic and neoplastic diseases.
Lactoferrin Its main action is to stimulate the immune system. Lactoferrin is a glycoprotein (the human form consists of 691 AA) that binds 2 atoms of Fe2+; it is present in breast milk and in many secretions (tears, nasal exudate, saliva, bronchial secretions, gastrointestinal juice, cervicovaginal mucus and seminal fluid) and is also synthesised in white blood cells, which release it at sites where an infectious process is present. Immunostimulant action: it can promote the growth and differentiation of T helper, CD4 and CD8 lymphocytes, which in turn stimulate the antibody response of B lymphocytes; it also appears to play an important role in the release and regulation of all the chemical mediators (cytokines, interleukins, lymphokines and TNF) responsible for recruiting immune system cells in case of infection or inflammation. Antibacterial action: by making free iron unavailable, an element essential for the growth of pathogenic bacteria, it makes these species more vulnerable to the action of antibiotics (an important example is the easier eradication of Helicobacter Pylori that can be obtained by taking lactoferrin during antibiotic therapy); in addition, a derivative of lactoferrin itself (lactoferricin, which derives from the enzymatic digestion of lactoferrin) appears to have its own antibacterial action.
Morinda Citrifolia L (Noni) Endowed with numerous biological activities, of particular interest being its immunomodulating, antibacterial, antiviral, anti-inflammatory and analgesic properties. The main components derived from the fruit and leaves include: terpenoids, flavonoids, linoleic acid, β-sitosterol, scopoletin, ursolic acid, proxeronine.
Ribes Nigrum L. Blackcurrant juice extract, rich in mineral salts, vitamin C and phenolic components, has documented antioxidant, immunomodulating and antimicrobial activity. In vitro studies show a stimulating action on macrophages and innate immunity. Active components: phenolic components such as anthocyanins, flavonoids, ellagitannins, gallotannins, proanthocyanidins, phenolic acids and polysaccharide extracts.
Lactic ferments An intake of lactic ferments is a fundamental aid in all situations where the balance of the intestinal microflora is altered. Bioimmunas Plus provides complete, balanced support of freeze-dried lactic ferments combined with the positive effect of FOS as prebiotics and Vitamin C.
Echinacea angustifolia Has stimulating activity on innate and adaptive immunity through stimulation of macrophage phagocytosis and the release of cytokines including interferon-gamma, providing supportive activity in opportunistic infections, rhinovirus infections and viral diseases of the upper respiratory tract. Active components: alkamide and caffeic acid derivatives.
Sambucus Nigra L. Known for its antioxidant, antiviral, antiproliferative (in vitro) and antimicrobial properties, black elder has an immunostimulant and antioxidant action and can support the course of colds and flu (in vitro studies show activity against the H1N1 virus) by stimulating the production of anti-inflammatory and pro-inflammatory cytokines with an immunoprotective action. Black elder extract is useful in people with reduced immune system efficiency, in paediatrics and during various infectious and neoplastic conditions. Active components: fruit-derived polyphenols, including flavonoids (hyperoside, isoquercitrin and rutoside) and anthocyanins.
Ingredients | | per 3.7 g sachet | per 100 g |
| NONI (juice) | 250 mg | 6.76 g |
| Blackcurrant buds | 150 mg | 4.05 g |
| Echinacea d.e. 4 % | 100 mg | 2.7 g |
| Elderberry d.e. 0.3 % | 100 mg | 2.7 g |
Lactic ferments of which:
L. acidophilus (DSM20079)
L. casei (DSM20011)
L. rhamnosus (SGL06)
B. bifidum (DSM20456) | 61 mg
2 billion
1.5 billion
1.5 billion
1 billion | 1.65 g
|
| Lactoferrin | 15 mg | 0.41 g |
How to use Children: one sachet a day dissolved in half a glass of water or fruit juice.
Adults: two sachets a day (one in the morning and one in the evening) dissolved in half a glass of water.
Preferably take on an empty stomach.
WarningsDo not exceed the recommended daily dose.
Keep out of the reach of children under three years of age.
Food supplements should not be used as a substitute for a varied diet.
Pregnant or breastfeeding women and children are advised to seek medical advice.
Size Box of 24 sachets of 3.7 g.
Bibliography - The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines Barak V, Halperin T, Kalickman I. Eur Cytokine Netw. 2001 Apr-Jun;12(2): 290-6.
- A systematic review on the sambuci fructus effect and efficacy profiles Vlachojannis JE, Cameron M, Chrubasik S. Phytother Res. 2010 Jan;24(1): 1-8. Review.
- Immunostimulatory effects of a polysaccharide-rich substance with antitumor activity isolated from black currant (Ribes nigrum L.). Takata R, Yamamoto R, Yanai T, Konno T, Okubo T. Biosci Biotechnol Biochem. 2005 Nov; 69(11): 2042-50.
- Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Bagchi D, Sen CK,Bagchi M,Atalay M. Biochemistry 2004 Jan 69(1): 75-80.
- Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. Seeram NP.J Agric Food Chem. 2008 Feb 13;56(3): 627-9
