Description Food supplement for the appearance and health of skin, hair and mucous membranes, for better function of the bone, joint, muscle and ligament system, and for an overall anti-ageing action. Projaluseon is a complete, innovative multi-component nutraceutical based on hyaluronic acid, carnosine, methylsulfonylmethane (MSM) and zinc. On the basis of the international literature it is indicated:
-For rehydrating the skin and against skin ageing (wrinkles, reduced elasticity, dryness, chrono/photo-ageing, loss of tone) (1-6).
-In joint degeneration: osteoarthritis/arthritis and joint effusion of the knee, hip, elbow, shoulder and ankle (7-10).
-In alopecia or other disorders of the skin appendages (1, 6, 11-13).
- In the healing processes of skin ulcers, surgical wounds and burns (1, 12-15).
-In post-menopausal vaginal atrophy and other conditions of the soft tissues (tendons, vocal cords, cornea, vitreous body, oral mucosa) (1, 12, 13, 16, 17).
Projaluseon is a supplement unique in its composition and doses:
-High-dose hyaluronic acid (100 mg), of plant origin and high molecular weight (1,600 kDa), which improve its bioavailability.
-Carnosine at medium-high doses with a marked anti-glycation action (and therefore against stiffness and loss of elasticity of collagen, elastin and connective tissue in general), antioxidant and with an alkalising action on tissues.
-MSM, which synergistically completes and amplifies the action of hyaluronic acid.
Zinc, in the form of 14% zinc gluconate at a dose of 10 mg, contributes to the maintenance of normal skin, nails and bones.
-Acid-resistant tablets with greater bioavailability.
Projaluseon is gluten-free, GMO-free and Vegan OK.
Properties Hyaluronic acid: high molecular weight (1,600 kDa), with moisturising and elasticising properties for skin, mucous membranes, joints and connective tissue in general.
Carnosine: a dipeptide with proven anti-glycation properties, against the AGEs typical of skin ageing, but also a powerful antioxidant and tissue alkaliser, and therefore a complete anti-ageing agent.
Methylsulfonylmethane (MSM): sulphur-based, it stabilises protein bonds, toning skin and hair and supporting cartilage synthesis.
Zinc: a mineral that contributes to the maintenance of normal skin, hair, nails and bones.
Ingredients L-carnosine, methylsulfonylmethane (MSM), hyaluronic acid sodium salt, microcrystalline cellulose; gelling agent: hydroxypropyl methylcellulose; anti-caking agent: colloidal silica; zinc gluconate; anti-caking agent: vegetable magnesium stearate.
Gluten-free. Nutritional information | Average values | Per 1 tab | Per 2 tabs |
| Hyaluronic acid sodium salt | 114.2 mg | 228.4 mg |
| equivalent to hyaluronic acid | 100 mg | 200 mg |
| L-Carnosine | 250 mg | 500 mg |
| Methylsulfonylmethane (MSM) | 200 mg | 400 mg |
| Zinc gluconate 14% | 10 mg | 20 mg |
Directions for use 1-2 tablets a day, preferably with breakfast and/or lunch; it is advisable to drink a few glasses of water in the 3-4 hours after intake.
Warnings Do not use during pregnancy. The product should be used as part of a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of the reach of children under 3 years of age.
Storage Store the product away from light in a cool, dry place.
Shelf life in unopened packaging: 36 months.
Size Pack of 30 acid-resistant 800 mg tablets in blister packs.
Net weight: 24 g.
Bibliography 1) Hyaluronic acid. A key molecule in skin aging. Papakonstantinou E, Roth M, Karakiulakis G Dermato-Endocrinology 2012 4:3, 253-258.
2) Ingested hyaluronan moisturizes dry skin. Kawada C, Yoshida T, Yoshida H et al Nutr J. 2014 Jul 11;13:70.
3) Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. Kawada C, Yoshida T, Yoshida H et al J Clin Biochem Nutr. 2015 Jan;56(1):66-73.
4) Skin beautification with oral non-hydrolized versions of carnosine and carcinine: effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. Babizhayev MA, Deyev AI, Savel'yeva EL et al J Dermatolog Treat. 2012 Oct;23(5):345-84 5) Carnosine and the processes of ageing. Hipkiss AR, Baye E, de Courten B Maturitas. 2016 Jun 22. 30134-7.
6) Carnosine: a versatile antioxidant and antiglycating agent Reddy VP, Garrett MR, Perry G et al Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
7) Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo- Controlled Study over a 12-Month Period. Toshiyuki T,Satoshi S,Toshihide S et al Scientific World Journal. 2012; 167928.
8) The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Nelson FR, Zvirbulis RA, Zonca B et al Rheumatol Int. 2015 Jan;35(1):43-52.
9) Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Brien S, Prescott P, Lewith G Evid Based Complement Alternat Med. 2011; 528403.
10) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study Debbi EM, Agar G, Fichman G et al Complement Altern Med. 2011; 11: 50.
11) A Nutritional Supplement Formulated with Peptides, Lipids, Collagen and Hyaluronic Acid Optimizes Key Aspects of Physical Appearance in Nails, Hair and Skin Yagoda MR, Gans E J Nutr Food Sci 2014, S5.
12) The biological role of carnosine and its possible applications in medicine Budzen S, Rymaszewska J. Adv Clin Exp Med. 2013 Sep-Oct;22(5):739-44.
13) Carnosine: its properties, functions and potential therapeutic applications Quinn PJ, Boldyrev AA, Formazuyk VE Mol Aspects Med 1992, 13(5): 379-444.
14) Action of carnosine on wound healing Nagai K et al. Surgery 1986, 100(5):815-821.
15) Dietary Peptides Improve Wound Healing Following Surgery Roberts P, Ward K,Santamauro J et al Nutrition , 3, 1998, 3: 266-269.
16) The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Ekin M, Yasar L, Savan K et al Arch Gynecol Obstet. 2011 Mar;283(3):539- 43.
17) Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis. La Galia T, Micali A, Puzzolo D et al International Journal of Clinical Medicine, 2014, 5: 617-624.
