Valeriana Canapa Relax 30 Divisible Tablets

Description
Herbal formula based on valerian root boosted with hemp seed powder, developed to promote relaxation on several levels and support physiological night-time rest, even in times of stress. Valerian is a valuable aid for restoring calm, reducing anxiety and improving sleep quality, while hemp supports the maintenance of correct cellular function, useful for an effective response to anxiety and stress. The high concentration of the functional ingredient promotes optimal sleep when taken before bed, while during the day it helps restore calm when anxious situations arise.

Properties
Valerian: its roots contain an essential oil with an antispasmodic effect, made up of numerous elements including: sesquiterpenes, specific iridoids called valepotriates, valerenic, hydroxyvalerenic and acetoxyvalerenic acid, borneol esters including bornyl acetate and isovalerate, aldehydes such as valerenal and ketones such as valeranone.
Valerian as a whole also has a hypotensive action, and the most active compounds appear to be valerenic acid, with an antispasmodic action, and valeranone, with anticonvulsant, hypotensive and sedative activity. Its relaxing action on the gastrointestinal muscles is traditionally used for intestinal well-being. Valerian is traditionally used to promote relaxation in case of nervousness and stress. It does not interfere with normal functions or lead to dependence. The root does not appear to prevent or impair driving or operating machinery, nor does it appear to cause drowsiness as a side effect.
Cannabis sativa: it does not contain delta-6-tetrahydrocannabinol (THC), the psychotropic component of the plant, except in traces below 1 ppm. The use of superfood hemp seeds in this formulation is linked to their high content of biologically active nutrients, involved in metabolic cycles that can be affected by a lack of these components in case of psychophysical fatigue. Hemp seeds are an excellent source of nutrients, particularly thanks to their content of essential amino acids and unsaturated fatty acids, present in the right ratio for dietary requirements. They contain high levels of L-arginine.
As well as essential amino acids and fatty acids, hemp seeds contain other bioactive and protective compounds that contribute to their health benefits, such as polyphenols and lignanamides. They are also an excellent source of minerals and vitamins. Minerals such as calcium, iron and phosphorus help counter tiredness, increasing energy production and supporting the body's well-being. Magnesium supports the relaxing action. Vitamin B1 contributes to normal energy-yielding metabolism and nervous system function, vitamin B2 is involved in the reduction of tiredness and fatigue, and vitamin B6 contributes to normal psychological function.

Ingredients
Valerian root powder (Valeriana officinalis L.), valerian root d.e. (Valeriana officinalis L.) std. 0.8% valerenic acid, bulking agent: microcrystalline cellulose; hemp seed powder (Cannabis sativa L.), anti-caking agents: magnesium salts of fatty acids and silicon dioxide.

Nutritional information

Average content per 2 tablets
Valerian powder	800 mg
Valerian d.e.	500 mg
Hemp powder	200 mg

Directions for use
Take 2 tablets a day, swallowed with a little water.

Warnings
Do not use while breastfeeding or when taking sedative, antiepileptic or hypnotic medicines.
Avoid in depression and insomnia with morning restlessness.

Storage
Store at room temperature.
Shelf life unopened: 36 months.

Size
Pack of 30 tablets.

Code 180951

References
Becker A. et al. "The anxiolytic effects of a Valerian extract is based on valerenic acid". BMC Complement. Altern. Med. 14:267. 2014.
Ditrói K. et al. "The alimentary impact of the hemp seed." Acta Alimentaria 42.3: 410-416. 2013.
Cary Leizer D. R. "The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition". J. Nutr. Funct. Med. Foods. 2000.
Kelber O. et al. "Valerian: no evidence for clinically relevant interactions". Evid Based Complement. Alternat. Med. doi: 10.1155/2014/879396. 2014.
Montserrat-de la Paz S. et al. "Hemp (Cannabis sativa L.) seed oil: analytical and phytochemical characterization of the unsaponifiable fraction". J. Agric. Food Chem. 62(5):1105-10. 2014.
Nunes A. et al. "Use of valerian in anxiety and sleep disorders: what is the best evidence?"Acta Med. Port. 24 Suppl 4:961-6. 2011.
Pichini S. et al. "The challenge of clinical application of FM2 cannabis oil produced in Italy for the treatment of neuropathic pain". Eur. Rev. Med. Pharmacol. Sci. 22(4):863-865. 2018.
Pinheiro M.L. et al. "Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study". J. Pharm. Bioallied Sci. 6(2):109-14. 2014.
Roh D. et al. "Valerian extract alters functional brain connectivity: A randomized double?blind placebo?controlled trial." Phytotherapy Research (2019).
Yan X. et al. "Characterization of lignanamides from hemp (Cannabis sativa L.) seed and their antioxidant and acetylcholinesterase inhibitory activities." Journal of agricultural and food chemistry 63.49: 10611-10619. 2015.
Zhou Y. et al. "Hemp (Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice." ACS omega 3.11:15988-15995. 2018.